Drug Information

Drug General Information
Drug ID
D0SH2X
Former ID
DIB011723
Drug Name
Amocarzine
Synonyms
Phenthiourezine; Thiocarbamazine; CGP-6140; S-80016
Drug Type
Small molecular drug
Indication Helminth infection [ICD9: 001-139; ICD10:A00-B99] Phase 3 [534433]
Company
Novartis AG
Formula
C18H21N5O2S
Canonical SMILES
CN1CCN(CC1)C(=S)Nc2ccc(Nc3ccc(cc3)[N+](=O)[O-])cc2
InChI
1S/C18H21N5O2S/c1-21-10-12-22(13-11-21)18(26)20-16-4-2-14(3-5-16)19-15-6-8-17(9-7-15)23(24)25/h2-9,19H,10-13H2,1H3,(H,20,26)
InChIKey
UFLRJROFPAGRPN-UHFFFAOYSA-N
CAS Number
CAS 36590-19-9
PubChem Compound ID
5464102
Target and Pathway
Target(s) Acetylcholinesterase Target Info Inhibitor [526781]
KEGG Pathway Glycerophospholipid metabolism
Cholinergic synapse
PANTHER Pathway Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database ATF-2 transcription factor network
PathWhiz Pathway Phospholipid Biosynthesis
WikiPathways Monoamine Transport
Biogenic Amine Synthesis
Acetylcholine Synthesis
Integrated Pancreatic Cancer Pathway
References
Ref 534433The safety and efficacy of amocarzine in African onchocerciasis and the influence of ivermectin on the clinical and parasitological response to treatment. Ann Trop Med Parasitol. 1997 Apr;91(3):281-96.
Ref 526781Activity, mechanism of action and pharmacokinetics of 2-tert-butylbenzothiazole and CGP 6140 (amocarzine) antifilarial drugs. Acta Trop. 1992 Aug;51(3-4):195-211.

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