Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09ADT
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| Former ID |
DNC000130
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| Drug Name |
ABT-418
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| Drug Type |
Small molecular drug
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| Indication | Alzheimer disease [ICD9: 331; ICD10:G30] | Discontinued in Phase 2 | [545652] | ||
| Formula |
C9H14N2O
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| Canonical SMILES |
CC1=NOC(=C1)C2CCCN2C
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| InChI |
1S/C9H14N2O/c1-7-6-9(12-10-7)8-4-3-5-11(8)2/h6,8H,3-5H2,1-2H3/t8-/m0/s1
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| InChIKey |
ILLGYRJAYAAAEW-QMMMGPOBSA-N
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| CAS Number |
CAS 147402-53-7
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Neuronal acetylcholine receptor protein, alpha-4 chain | Target Info | Agonist | [537889] | |
| Nicotinic acetylcholine receptor | Target Info | Agonist | [534879] | ||
| Neuronal acetylcholine receptor protein, beta-2 chain | Target Info | Agonist | [535007], [537889] | ||
| Reactome | Highly sodium permeable acetylcholine nicotinic receptors | ||||
| Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | |||||
| Highly calcium permeable nicotinic acetylcholine receptorsR-HSA-629587:Highly sodium permeable acetylcholine nicotinic receptors | |||||
| Highly calcium permeable nicotinic acetylcholine receptors | |||||
| References | |||||
| Ref 534879 | Enhancement of sustained attention performance by the nicotinic acetylcholine receptor agonist ABT-418 in intact but not basal forebrain-lesioned rats. Psychopharmacology (Berl). 1999 May;144(2):175-82. | ||||
| Ref 535007 | Nicotine, brain nicotinic receptors, and neuropsychiatric disorders. Arch Med Res. 2000 Mar-Apr;31(2):131-44. | ||||
| Ref 537889 | (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: II. In vivo characterization. J Pharmacol Exp Ther. 1994 Jul;270(1):319-28. | ||||
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