Drug Information

Drug General Information
Drug ID
D09MON
Former ID
DIB011328
Drug Name
A-75998
Indication Hormone deficiency [ICD10:E00-E90] Discontinued in Phase 1 [545556]
Company
Abbott Laboratories
Formula
C80H104ClN15O14
Canonical SMILES
N1(C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](N(<br />C(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)C<br />)Cc2cc3c(cc2)cccc3)Cc2ccc(Cl)cc2)Cc2cnccc2)CO)C)Cc2ccc(<br />cc2)O)CCCCNC(=O)c2cnccc2)CC(C)C)CCCCNC(C)C)[C@H](C(=O)N<br />[C@@H](C(=O)N)C)CCC1
CAS Number
CAS 135215-95-1
PubChem Compound ID
44383749
Target and Pathway
Target(s) Gonadotropin-releasing hormone receptor Target Info Antagonist [533603]
KEGG Pathway Neuroactive ligand-receptor interaction
GnRH signaling pathway
NetPath Pathway IL1 Signaling Pathway
IL2 Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Hormone ligand-binding receptors
G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 545556Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003694)
Ref 533603Physicochemical properties of A-75998, an antagonist of luteinizing hormone releasing hormone. J Pharm Sci. 1995 Aug;84(8):953-8.

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