Drug Information

Drug General Information
Drug ID
D03HVV
Former ID
DIB006716
Drug Name
Efaproxyn
Synonyms
Efaproxiral; RSR13
Drug Type
Small molecular drug
Indication Lung cancer [ICD9: 162; ICD10:C33-C34] Phase 3 [521598]
Company
Allos Therapeutics
Formula
C20H23NO4
Canonical SMILES
Cc1cc(C)cc(NC(=O)Cc2ccc(OC(C)(C)C(=O)O)cc2)c1
InChI
1S/C20H23NO4/c1-13-9-14(2)11-16(10-13)21-18(22)12-15-5-7-17(8-6-15)25-20(3,4)19(23)24/h5-11H,12H2,1-4H3,(H,21,22)(H,23,24)
InChIKey
BNFRJXLZYUTIII-UHFFFAOYSA-N
PubChem Compound ID
122335
Target and Pathway
Target(s) Hemoglobin Target Info Inhibitor [527506]
KEGG Pathway African trypanosomiasis
Malaria
Reactome Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Scavenging of heme from plasma
WikiPathways Binding and Uptake of Ligands by Scavenger Receptors
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
Factors involved in megakaryocyte development and platelet production
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient Network
References
Ref 521598ClinicalTrials.gov (NCT00083304) Whole Brain Radiation Therapy With Oxygen, With or Without RSR13, in Women With Brain Metastases From Breast Cancer. U.S. National Institutes of Health.
Ref 527506Increased oxygenation of intracranial tumors by efaproxyn (efaproxiral), an allosteric hemoglobin modifier: In vivo EPR oximetry study. Int J Radiat Oncol Biol Phys. 2005 Apr 1;61(5):1503-9.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.