Drug Information

Drug General Information
Drug ID
D0PN8D
Former ID
DNC004503
Drug Name
1-(7-Methoxy-naphthalen-2-yl)-piperazine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534528]
Formula
C15H18N2O
Canonical SMILES
COC1=CC2=C(C=CC(=C2)N3CCNCC3)C=C1
InChI
1S/C15H18N2O/c1-18-15-5-3-12-2-4-14(10-13(12)11-15)17-8-6-16-7-9-17/h2-5,10-11,16H,6-9H2,1H3
InChIKey
FRTFBUOBLXTGSL-UHFFFAOYSA-N
PubChem Compound ID
44351692
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Inhibitor [534528]
5-hydroxytryptamine 1D receptor Target Info Inhibitor [534528]
5-hydroxytryptamine 1B receptor Target Info Inhibitor [534528]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04024:cAMP signaling pathway
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
GPCR downstream signaling
References
Ref 534528J Med Chem. 1997 Nov 21;40(24):3974-8.5-HT1B receptor antagonist properties of novel arylpiperazide derivatives of 1-naphthylpiperazine.
Ref 534528J Med Chem. 1997 Nov 21;40(24):3974-8.5-HT1B receptor antagonist properties of novel arylpiperazide derivatives of 1-naphthylpiperazine.

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