Drug Information

Drug General Information
Drug ID
D07JDC
Former ID
DIB019064
Drug Name
carvacrol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539619]
Formula
C10H14O
InChI
InChI=1S/C10H14O/c1-7(2)9-5-4-8(3)10(11)6-9/h4-7,11H,1-3H3
InChIKey
RECUKUPTGUEGMW-UHFFFAOYSA-N
PubChem Compound ID
10364
PubChem Substance ID
12027, 72179, 587993, 614462, 3155675, 4965060, 8157482, 10524223, 11528571, 12055917, 15194720, 24853174, 24857025, 24900943, 29203921, 50782553, 53801081, 56369115, 57326160, 74382164, 85087098, 87565235, 88834878, 92711002, 93165944, 99246150, 103199240, 104098282, 104323093, 104669251, 117366423, 118309331, 123071442, 125351482, 126565361, 126631305, 126646199, 126669030, 128713154, 129116125, 129276130, 129577075, 131316276, 134977964, 135306122, 135610165, 135715960, 136910575, 137003575, 142269769
Target and Pathway
Target(s) TRPM7 Target Info Blocker (channel blocker) [529910]
Transient receptor potential cation channel subfamily V member 3 Target Info Activator [528138]
KEGG Pathway Inflammatory mediator regulation of TRP channels
Reactome TRP channels
References
Ref 539619(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2497).
Ref 528138Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nat Neurosci. 2006 May;9(5):628-35. Epub 2006 Apr 16.
Ref 529910Carvacrol is a novel inhibitor of Drosophila TRPL and mammalian TRPM7 channels. Cell Calcium. 2009 Mar;45(3):300-9.

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