TTD | Drug: D03XMD

Drug General Information
Drug ID	D03XMD
Former ID	DIB020908
Drug Name	SB 699551
Synonyms	SB-699,551; SB699551
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[539705]
Formula	C34H45N3O
InChI	InChI=1S/C34H45N3O/c1-36(2)24-25-37(34(38)21-16-28-10-6-7-11-28)27-31-14-19-33(20-15-31)32-17-12-30(13-18-32)26-35-23-22-29-8-4-3-5-9-29/h3-5,8-9,12-15,17-20,28,35H,6-7,10-11,16,21-27H2,1-2H3
InChIKey	SEQAMPXQRKYYQF-UHFFFAOYSA-N
PubChem Compound ID	11168182
PubChem Substance ID	16247727, 23360761, 42222932, 80741525, 124960930, 135651015, 136367792, 137010141, 162223697, 162914865, 170485792, 223681798, 245314210
Target and Pathway
Target(s)	5-hydroxytryptamine 5A receptor	Target Info	Antagonist	[527628]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapse
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome	Serotonin receptors
Reactome	G alpha (i) signalling events
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 539705	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 264).
Ref 527628	Discovery of a potent and selective 5-ht5A receptor antagonist by high-throughput chemistry. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4014-8.

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Drug Information