Drug Information

Drug General Information
Drug ID
D0F3AN
Former ID
DIB020268
Drug Name
LY2119620
Synonyms
LY 2119620; LY-2119620
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541981]
Formula
C19H24ClN5O3S
InChI
InChI=1S/C19H24ClN5O3S/c1-10-13-15(21)16(17(27)22-11-3-4-11)29-19(13)23-18(14(10)20)28-9-12(26)25-7-5-24(2)6-8-25/h11H,3-9,21H2,1-2H3,(H,22,27)
InChIKey
TYTGOXSAAQWLPJ-UHFFFAOYSA-N
PubChem Compound ID
57664406
PubChem Substance ID
137525773, 165248795, 178103520, 223427125, 237166628, 244861976, 249714996, 252470068
Target and Pathway
Target(s) Muscarinic receptor Target Info Modulator (allosteric modulator) [532770]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton
PathWhiz Pathway Muscle/Heart Contraction
Reactome Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 541981(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6938).
Ref 532770Characterization of the novel positive allosteric modulator, LY2119620, at the muscarinic M(2) and M(4) receptors. Mol Pharmacol. 2014 Jul;86(1):106-15.

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