Drug Information

Drug General Information
Drug ID
D07GXY
Former ID
DIB020732
Drug Name
piribedil
Drug Type
Small molecular drug
Indication Discovery agent Investigative [468089]
Formula
C16H18N4O2
InChI
InChI=1S/C16H18N4O2/c1-4-17-16(18-5-1)20-8-6-19(7-9-20)11-13-2-3-14-15(10-13)22-12-21-14/h1-5,10H,6-9,11-12H2
InChIKey
OQDPVLVUJFGPGQ-UHFFFAOYSA-N
PubChem Compound ID
4850
PubChem Substance ID
3318349, 5518527, 8152983, 10589522, 11111687, 11111688, 11113867, 11467008, 11468128, 11486666, 14776022, 26752039, 29223931, 47291247, 47365330, 47515441, 47662430, 47736619, 47885534, 47885535, 48110578, 48334631, 48853191, 49699322, 50036468, 50104696, 50647529, 51091642, 57309591, 57322489, 61104879, 85209232, 85788361, 85788799, 88943151, 90341513, 92308933, 92719149, 93616730, 103113732, 104171222, 104307610, 105856731, 117603465, 124365751, 124750130, 124881234, 124881235, 124881236, 125433414
Target and Pathway
Target(s) D(3) dopamine receptor Target Info Agonist [526443]
5-hydroxytryptamine 2B receptor Target Info Antagonist [526443]
5-hydroxytryptamine 1A receptor Target Info Agonist [526443]
D(4) dopamine receptor Target Info Antagonist [526443]
D(2) dopamine receptor Target Info Agonist [526443]
Alpha-2C adrenergic receptor Target Info Antagonist [526443]
KEGG Pathway Neuroactive ligand-receptor interaction
Dopaminergic synapsehsa04020:Calcium signaling pathway
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04024:cAMP signaling pathway
Serotonergic synapsehsa04080:Neuroactive ligand-receptor interaction
Dopaminergic synapsehsa04015:Rap1 signaling pathway
cAMP signaling pathway
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholismhsa04022:cGMP-PKG signaling pathway
PANTHER Pathway 5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Nicotine pharmacodynamics pathwayP00002:Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome Dopamine receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (i) signalling eventsR-HSA-390696:Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolism
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, OtherWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
Genes and (Common) Pathways Underlying Drug Addiction
GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
Nicotine Activity on Dopaminergic NeuronsWP58:Monoamine GPCRs
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
References
Ref 468089(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 49).
Ref 526443Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes. J Pharmacol Exp Ther. 2002 Nov;303(2):791-804.

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