Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0L3RY
|
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| Former ID |
DNC007404
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| Drug Name |
3-methoxy-N-(4-methylthiazol-2-yl)benzamide
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [528186] | ||
| Formula |
C12H12N2O2S
|
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| Canonical SMILES |
CC1=CSC(=N1)NC(=O)C2=CC(=CC=C2)OC
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| InChI |
1S/C12H12N2O2S/c1-8-7-17-12(13-8)14-11(15)9-4-3-5-10(6-9)16-2/h3-7H,1-2H3,(H,13,14,15)
|
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| InChIKey |
PAGPVSQZNPBQLP-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Metabotropic glutamate receptor 5 | Target Info | Inhibitor | [528186] | |
| mRNA of human 5-lipoxygenase | Target Info | Inhibitor | [528805] | ||
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Gap junction | |||||
| Long-term potentiation | |||||
| Retrograde endocannabinoid signaling | |||||
| Glutamatergic synapse | |||||
| Huntington's diseasehsa00590:Arachidonic acid metabolism | |||||
| Metabolic pathways | |||||
| Serotonergic synapse | |||||
| Ovarian steroidogenesis | |||||
| Toxoplasmosis | |||||
| NetPath Pathway | IL4 Signaling Pathway | ||||
| PathWhiz Pathway | Arachidonic Acid Metabolism | ||||
| References | |||||
| Ref 528186 | Bioorg Med Chem Lett. 2006 Jul 1;16(13):3371-5. Epub 2006 May 5.Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists. | ||||
| Ref 528805 | J Med Chem. 2007 May 31;50(11):2640-6. Epub 2007 Apr 27.Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening. | ||||
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