Drug Information

Drug General Information
Drug ID
D0W6PV
Former ID
DIB021100
Drug Name
U46609
Synonyms
9,11-epoxymethano-PGH2
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539269]
Formula
C20H32O5
InChI
InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1
InChIKey
YIBNHAJFJUQSRA-YNNPMVKQSA-N
PubChem Compound ID
445049
PubChem Substance ID
3717, 3727078, 4265958, 7889838, 8143214, 36887877, 53787804, 57404655, 75696323, 126524011, 135256927, 135651288, 137001594, 152255424, 160675519, 162223440, 172097183, 178101215, 179292987, 198983831, 237249632, 241079802, 252469125
Target and Pathway
Target(s) Thromboxane A2 receptor Target Info Agonist [526825]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Platelet activation
Reactome Prostanoid ligand receptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Thromboxane signalling through TP receptor
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Signal amplification
GPCR ligand binding
GPCR downstream signaling
References
Ref 539269(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1972).
Ref 526825Effects of KW-3635, a novel dibenzoxepin derivative of a selective thromboxane A2 antagonist, on human, guinea pig and rat platelets. Jpn J Pharmacol. 1992 Jul;59(3):357-64.

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