Drug Information

Drug General Information
Drug ID
D0Y3EG
Former ID
DIB018601
Drug Name
3-MATIDA
Synonyms
alpha-amino-5-carboxy-3-methyl-2-thiopheneacetic acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540342]
Formula
C8H9NO4S
InChI
InChI=1S/C8H9NO4S/c1-3-2-4(7(10)11)14-6(3)5(9)8(12)13/h2,5H,9H2,1H3,(H,10,11)(H,12,13)
InChIKey
KOMWRBFEDDEWEP-UHFFFAOYSA-N
PubChem Compound ID
10398360
PubChem Substance ID
15414685, 22747412, 26753227, 34117953, 77837595, 85227136, 91746224, 137270715, 162023098, 163125590, 177748547, 178100409, 204399711, 226955990, 241375815, 242136395, 245613959, 252156349
Target and Pathway
Target(s) Metabotropicglutamate receptor 1 Target Info Antagonist [526337]
KEGG Pathway Calcium signaling pathway
FoxO signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Long-term depression
Estrogen signaling pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 540342(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3396).
Ref 526337The novel and systemically active metabotropic glutamate 1 (mGlu1) receptor antagonist 3-MATIDA reduces post-ischemic neuronal death. Neuropharmacology. 2002 May;42(6):741-51.

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