Drug Information

Drug General Information
Drug ID
D02DPK
Former ID
DIB020022
Drug Name
hyp 9
Synonyms
2,4-(1-keto-hexyl) phloroglucinol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540699]
Formula
C18H26O5
InChI
InChI=1S/C18H26O5/c1-3-5-7-9-12(19)16-14(21)11-15(22)17(18(16)23)13(20)10-8-6-4-2/h11,21-23H,3-10H2,1-2H3
InChIKey
JRHOSBCIYWDGHN-UHFFFAOYSA-N
PubChem Compound ID
15659415
PubChem Substance ID
90326623, 103185720, 128316271, 162248806, 178100924, 235123433
Target and Pathway
Target(s) Short transient receptor potential channel 6 Target Info Activator [530580]
PANTHER Pathway Alzheimer disease-presenilin pathway
Pathway Interaction Database Endothelins
Nephrin/Neph1 signaling in the kidney podocyte
EPO signaling pathway
PAR1-mediated thrombin signaling events
Reactome Effects of PIP2 hydrolysis
TRP channels
Role of second messengers in netrin-1 signaling
WikiPathways Primary Focal Segmental Glomerulosclerosis FSGS
Platelet homeostasis
Netrin-1 signaling
GPCR downstream signaling
Effects of PIP2 hydrolysis
References
Ref 540699(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4101).
Ref 530580Simple 2,4-diacylphloroglucinols as classic transient receptor potential-6 activators--identification of a novel pharmacophore. Mol Pharmacol. 2010 Mar;77(3):368-77.

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