Drug Information

Drug General Information
Drug ID
D03OEN
Former ID
DNC013218
Drug Name
N-butyl-2-(5-nitro-1H-indol-3-yl)-2-oxoacetamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528709]
Formula
C14H15N3O4
Canonical SMILES
CCCCNC(=O)C(=O)C1=CNC2=C1C=C(C=C2)[N+](=O)[O-]
InChI
1S/C14H15N3O4/c1-2-3-6-15-14(19)13(18)11-8-16-12-5-4-9(17(20)21)7-10(11)12/h4-5,7-8,16H,2-3,6H2,1H3,(H,15,19)
InChIKey
FFNPFJOEAUFBBY-UHFFFAOYSA-N
PubChem Compound ID
16124919
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Inhibitor [528709]
Gamma-aminobutyric acid receptor subunit beta-2 Target Info Inhibitor [528709]
Gamma-aminobutyric acid receptor Target Info Inhibitor [528709]
Gamma-aminobutyric acid receptor subunit gamma-2 Target Info Inhibitor [528709]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
Serotonergic synapse
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 528709J Med Chem. 2007 Apr 5;50(7):1627-34. Epub 2007 Mar 3.Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-selective ligands.
Ref 528709J Med Chem. 2007 Apr 5;50(7):1627-34. Epub 2007 Mar 3.Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-selective ligands.

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