Drug Information

Drug General Information
Drug ID
D0X0OP
Former ID
DIB018800
Drug Name
alkyl OMPT
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539930]
Formula
C22H45O5PS
InChI
InChI=1S/C22H45O5PS/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-26-20-22(25-2)21-27-28(23,24)29/h10-11,22H,3-9,12-21H2,1-2H3,(H2,23,24,29)/b11-10-/t22-/m0/s1
InChIKey
FEHMGBUAJYEJMW-YRBAHSOBSA-N
PubChem Compound ID
56947064
PubChem Substance ID
135649916
Target and Pathway
Target(s) Lysophosphatidate-3 receptor Target Info Agonist [528359]
Lysophosphatidic acid receptor Edg-2 Target Info Agonist [528359]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Pathways in cancerhsa04015:Rap1 signaling pathway
Gap junction
Pathways in cancer
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Pathway Interaction Database LPA receptor mediated eventslysophospholipid_pathway:LPA receptor mediated events
Reactome G alpha (q) signalling events
G alpha (i) signalling events
Lysosphingolipid and LPA receptorsR-HSA-416476:G alpha (q) signalling events
Lysosphingolipid and LPA receptors
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP289:Myometrial Relaxation and Contraction Pathways
Small Ligand GPCRs
GPCR downstream signaling
References
Ref 539930(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2913).
Ref 528359Phosphorothioate analogues of alkyl lysophosphatidic acid as LPA3 receptor-selective agonists. ChemMedChem. 2006 Mar;1(3):376-83.

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