Drug Information

Drug General Information
Drug ID
D02MVR
Former ID
DNC011797
Drug Name
3-(1,2,3,6-Tetrahydro-pyridin-4-yl)-1H-indole
Drug Type
Small molecular drug
Indication Discovery agent Investigative [532389]
Formula
C13H14N2
Canonical SMILES
C1CNCC=C1C2=CNC3=CC=CC=C32
InChI
1S/C13H14N2/c1-2-4-13-11(3-1)12(9-15-13)10-5-7-14-8-6-10/h1-5,9,14-15H,6-8H2
InChIKey
CIRSPTXGPFAXRE-UHFFFAOYSA-N
PubChem Compound ID
2761023
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Inhibitor [532389]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 532389J Med Chem. 1990 Aug;33(8):2087-93.3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole.
Ref 532389J Med Chem. 1990 Aug;33(8):2087-93.3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole.

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