Drug Information

Drug General Information
Drug ID
D0Z9XV
Former ID
DIB020826
Drug Name
RO1138452
Synonyms
Ro-1138452
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539266]
Formula
C19H23N3O
InChI
InChI=1S/C19H23N3O/c1-14(2)23-18-9-5-16(6-10-18)13-15-3-7-17(8-4-15)22-19-20-11-12-21-19/h3-10,14H,11-13H2,1-2H3,(H2,20,21,22)
InChIKey
GYYRMJMXXLJZAB-UHFFFAOYSA-N
PubChem Compound ID
9839644
PubChem Substance ID
14800893, 24138151, 44937730, 74815424, 103169318, 125335037, 135650911, 162817089, 163642090, 184529067, 198960132, 230592157, 241053574, 245955993, 252457534, 252465338
Target and Pathway
Target(s) Prostacyclin receptor Target Info Antagonist [527911]
KEGG Pathway Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Platelet activation
Pathway Interaction Database Thromboxane A2 receptor signaling
PathWhiz Pathway Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin
Reactome Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
Endothelin Pathways
Platelet homeostasis
GPCR ligand binding
GPCR downstream signaling
References
Ref 539266(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1969).
Ref 527911RO1138452 and RO3244794: characterization of structurally distinct, potent and selective IP (prostacyclin) receptor antagonists. Br J Pharmacol. 2006 Feb;147(3):335-45.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.