Drug Information

Drug General Information
Drug ID
D0WB8E
Former ID
DIB020778
Drug Name
pyrazolone, 1
Synonyms
compound 43 [PMID:23160941]; compound 43 [PMID:16697190]
Drug Type
Small molecular drug
Indication Discovery agent Investigative [532123]
Formula
C20H21ClN4O2
InChI
InChI=1S/C20H21ClN4O2/c1-13(2)18-17(23-20(27)22-15-11-9-14(21)10-12-15)19(26)25(24(18)3)16-7-5-4-6-8-16/h4-13H,1-3H3,(H2,22,23,27)
InChIKey
PAEBEUZTAPIOIO-UHFFFAOYSA-N
PubChem Compound ID
24776341
PubChem Substance ID
49700799, 56182510, 103492756, 170474643, 178102456, 198966739, 223370182, 245853652, 249895989, 252158224
Target and Pathway
Target(s) FMLP-related receptor I Target Info Agonist [528203]
FMLP receptor Target Info Agonist [532123]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Staphylococcus aureus infection
NetPath Pathway Leptin Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signalingupa_upar_pathway:Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome G alpha (q) signalling events
G alpha (i) signalling eventsR-HSA-418594:G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
Human Complement System
GPCR downstream signaling
References
Ref 532123Functional characterization of three mouse formyl peptide receptors. Mol Pharmacol. 2013 Feb;83(2):389-98.
Ref 528203Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3713-8. Epub 2006 May 11.
Ref 532123Functional characterization of three mouse formyl peptide receptors. Mol Pharmacol. 2013 Feb;83(2):389-98.

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