Drug Information

Drug General Information
Drug ID
D0X2MQ
Former ID
DIB018493
Drug Name
17-phenyl-omega-trinor-PGE2
Synonyms
17-phenyl-omega-trinor-prostaglandin E2; 17-phenyl-trinor-PGE2; 17-Ph-omega-trinor-PGE2; 17-phenyl-PGE2
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539213]
Formula
C23H30O5
InChI
InChI=1S/C23H30O5/c24-18(13-12-17-8-4-3-5-9-17)14-15-20-19(21(25)16-22(20)26)10-6-1-2-7-11-23(27)28/h1,3-6,8-9,14-15,18-20,22,24,26H,2,7,10-13,16H2,(H,27,28)/b6-1-,15-14+/t18-,19+,20+,22+/m0/s1
InChIKey
FOBVMYJQWZOGGJ-XYRJXBATSA-N
PubChem Compound ID
5283068
PubChem Substance ID
4266001, 7978573, 11038725, 15474352, 26754834, 26754835, 39316485, 47440000, 47736222, 50110796, 57358833, 74660904, 85787435, 92309785, 99300699, 99302217, 104046454, 113859000, 131342668, 135651383, 137146293, 142622838, 143020475, 179150412, 186016875, 229390806, 242475231, 250134045, 252377742, 252455509, 252457339, 252464504
Target and Pathway
Target(s) Prostaglandin E2 receptor, EP1 subtype Target Info Agonist [534595]
Prostaglandin E2receptor, EP2 subtype Target Info Agonist [534595]
Prostaglandin E2 receptor EP3 subtype Target Info Agonist [534478]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Pathways in cancerhsa04024:cAMP signaling pathway
Inflammatory mediator regulation of TRP channels
Renin secretion
Pathways in cancerhsa04020:Calcium signaling pathway
cAMP signaling pathway
Regulation of lipolysis in adipocytes
Pathways in cancer
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway PI3 kinase pathway
Reactome Prostanoid ligand receptors
G alpha (q) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (s) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (i) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signalingWP98:Prostaglandin Synthesis and Regulation
Ovarian Infertility Genes
GPCR downstream signaling
References
Ref 539213(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1912).
Ref 534478Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24.
Ref 534595Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes. Eur J Pharmacol. 1997 Dec 11;340(2-3):227-41.

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