Drug Information

Drug General Information
Drug ID
D0D4LF
Former ID
DIB020573
Drug Name
NS1738
Synonyms
NS-1738
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540617]
Formula
C14H9Cl2F3N2O2
InChI
InChI=1S/C14H9Cl2F3N2O2/c15-8-2-4-12(22)11(6-8)21-13(23)20-10-5-7(14(17,18)19)1-3-9(10)16/h1-6,22H,(H2,20,21,23)
InChIKey
OUDXRNQPVSMGDW-UHFFFAOYSA-N
PubChem Compound ID
310378
PubChem Substance ID
128152, 6871716, 8884018, 16243908, 34849104, 52715176, 99030144, 103578895, 104534978, 125720178, 135698839, 137161671, 139740943, 160853491, 162860534, 170485773, 178100826, 198966210, 204362839, 218929195, 223370044, 224104308, 227667965, 243962120, 251963169, 252156934
Target and Pathway
Target(s) Neuronal acetylcholine receptor protein, beta-2 chain Target Info Blocker (channel blocker) [528946]
Acetylcholine receptor Target Info Blocker (channel blocker) [528946]
Neuronal acetylcholine receptor protein, alpha-7 chain Target Info Modulator (allosteric modulator) [528946]
KEGG Pathway Neuroactive ligand-receptor interaction
Cholinergic synapse
Nicotine addictionhsa04080:Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
Nicotine addiction
Chemical carcinogenesis
PANTHER Pathway Nicotinic acetylcholine receptor signaling pathway
Nicotine pharmacodynamics pathwayP00003:Alzheimer disease-amyloid secretase pathway
Reactome Highly sodium permeable acetylcholine nicotinic receptors
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Highly calcium permeable nicotinic acetylcholine receptorsR-HSA-390648:Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
Highly calcium permeable postsynaptic nicotinic acetylcholine receptorsR-HSA-629594:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Nicotine Activity on Dopaminergic NeuronsWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellWP706:SIDS Susceptibility Pathways
References
Ref 540617(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4000).
Ref 528946An allosteric modulator of the alpha7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo. J Pharmacol Exp Ther. 2007 Oct;323(1):294-307. Epub 2007 Jul 11.

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