Drug Information

Drug General Information
Drug ID
D0G7TT
Former ID
DIB019694
Drug Name
D-AP4
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538919]
Formula
C4H10NO5P
InChI
InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m1/s1
InChIKey
DDOQBQRIEWHWBT-GSVOUGTGSA-N
PubChem Compound ID
1550579
PubChem Substance ID
11110720, 11113373, 11113374, 11545104, 32249998, 47736771, 47736772, 78666741, 92466464, 110473208, 117682322, 118503878, 124879122, 125329048, 131342580, 135650159, 140384205, 160671828, 162658134, 237693815, 241181545, 241375169, 244495148
Target and Pathway
Target(s) Metabotropic glutamate receptor 8 Target Info Agonist [534561]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 538919(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1443).
Ref 534561Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells. Brain Res Mol Brain Res. 1998 Jan;53(1-2):88-97.

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