Drug Information

Drug General Information
Drug ID
D0G3RN
Former ID
DNC008439
Drug Name
VUF-10214
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529387]
Formula
C13H14Cl2N4O
Canonical SMILES
CN1CCN(CC1)C2=NC3=CC(=C(C=C3NC2=O)Cl)Cl
InChI
1S/C13H14Cl2N4O/c1-18-2-4-19(5-3-18)12-13(20)17-11-7-9(15)8(14)6-10(11)16-12/h6-7H,2-5H2,1H3,(H,17,20)
InChIKey
MFJVHWQDKIEBCM-UHFFFAOYSA-N
PubChem Compound ID
11301441
Target and Pathway
Target(s) Histamine H3 receptor Target Info Inhibitor [529387]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Histamine receptors
G alpha (i) signalling events
WikiPathways Monoamine Transport
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 529387J Med Chem. 2008 Apr 24;51(8):2457-67. Epub 2008 Mar 22.Fragment based design of new H4 receptor-ligands with anti-inflammatory properties in vivo.
Ref 529387J Med Chem. 2008 Apr 24;51(8):2457-67. Epub 2008 Mar 22.Fragment based design of new H4 receptor-ligands with anti-inflammatory properties in vivo.

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