Drug Information

Drug General Information
Drug ID
D03HJW
Former ID
DIB019941
Drug Name
GSK1016790A
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467539]
Formula
C28H32Cl2N4O6S2
InChI
InChI=1S/C28H32Cl2N4O6S2/c1-17(2)13-21(31-26(36)24-14-18-5-3-4-6-23(18)41-24)27(37)33-9-11-34(12-10-33)28(38)22(16-35)32-42(39,40)25-8-7-19(29)15-20(25)30/h3-8,14-15,17,21-22,32,35H,9-13,16H2,1-2H3,(H,31,36)/t21-,22-/m0/s1
InChIKey
IVYQPSHHYIAUFO-VXKWHMMOSA-N
PubChem Compound ID
23630211
PubChem Substance ID
46491689, 56018250, 126522388, 137275910, 141939763, 162248359, 178101022, 208265201, 224232351, 230882006, 248350743
Target and Pathway
Target(s) Transient receptor potential cation channel subfamily V member 4 Target Info Activator [529487]
KEGG Pathway Inflammatory mediator regulation of TRP channels
Reactome TRP channels
References
Ref 467539(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4205).
Ref 529487N-((1S)-1-{[4-((2S)-2-{[(2,4-dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a novel and potent transient receptor potential vanilloid 4 channel agonist induces urinary bladder contraction and hyperactivity: Part I. J Pharmacol Exp Ther. 2008 Aug;326(2):432-42.

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