Drug Information

Drug General Information
Drug ID
D0NY1J
Former ID
DIB021044
Drug Name
TG7-171
Drug Type
Small molecular drug
Indication Discovery agent Investigative [543191]
Formula
C24H31N3O
InChI
InChI=1S/C24H31N3O/c1-4-26(5-2)22-13-11-20(12-14-22)18-24(28)25-15-8-16-27-19(3)17-21-9-6-7-10-23(21)27/h6-7,9-14,17H,4-5,8,15-16,18H2,1-3H3,(H,25,28)
InChIKey
NBHMEDLJHJCMEZ-UHFFFAOYSA-N
PubChem Compound ID
91827368
Target and Pathway
Target(s) Prostaglandin E2receptor, EP2 subtype Target Info Antagonist [532849]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
Renin secretion
Pathways in cancer
Reactome Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Ovarian Infertility Genes
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 543191(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8546).
Ref 532849Development of second generation EP2 antagonists with high selectivity. Eur J Med Chem. 2014 Jul 23;82:521-35.

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