Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D05SVA
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| Former ID |
DNC007222
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| Drug Name |
5-(piperidin-4-yl)isoxazol-3-ol
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| Synonyms |
5-Piperidin-4-yl-isoxazol-3-ol
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [527382] | ||
| Formula |
C8H12N2O2
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| Canonical SMILES |
C1CNCCC1C2=CC(=O)NO2
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| InChI |
1S/C8H12N2O2/c11-8-5-7(12-10-8)6-1-3-9-4-2-6/h5-6,9H,1-4H2,(H,10,11)
|
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| InChIKey |
YYOYGSTYWVHCJR-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Gamma-aminobutyric acid receptor subunit gamma-2 | Target Info | Inhibitor | [527382] | |
| Gamma-aminobutyric acid receptor | Target Info | Inhibitor | [528744] | ||
| Gamma-aminobutyric acid receptor subunit beta-2 | Target Info | Inhibitor | [527382] | ||
| Gamma-aminobutyric acid receptor subunit alpha-1 | Target Info | Inhibitor | [527382] | ||
| WikiPathways | Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||||
| Iron uptake and transportWP706:SIDS Susceptibility Pathways | |||||
| Iron uptake and transport | |||||
| References | |||||
| Ref 527382 | J Med Chem. 2005 Jan 27;48(2):427-39.Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling. | ||||
| Ref 528744 | J Med Chem. 2007 Apr 19;50(8):1988-92. Epub 2007 Mar 22.4-aryl-5-(4-piperidyl)-3-isoxazolol GABAA antagonists: synthesis, pharmacology, and structure-activity relationships. | ||||
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