Drug Information

Drug General Information
Drug ID
D08OCG
Former ID
DIB020774
Drug Name
PTBE
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538880]
Formula
C22H26N4O4
InChI
InChI=1S/C22H26N4O4/c1-3-6-19-20(12-11-18(15(2)27)21(19)28)30-14-5-4-13-29-17-9-7-16(8-10-17)22-23-25-26-24-22/h7-12,28H,3-6,13-14H2,1-2H3,(H,23,24,25,26)
InChIKey
FEEONEKLFGDWHR-UHFFFAOYSA-N
PubChem Compound ID
10047169
PubChem Substance ID
15030626, 22469840, 44164220, 57374084, 80699971, 103448321, 104041508, 135650863, 231987449, 243426244
Target and Pathway
Target(s) Metabotropic glutamate receptor 2 Target Info Modulator (allosteric modulator) [527176]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
Cocaine addiction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group II pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signaling
References
Ref 538880(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1403).
Ref 527176Phenyl-tetrazolyl acetophenones: discovery of positive allosteric potentiatiors for the metabotropic glutamate 2 receptor. J Med Chem. 2004 Aug 26;47(18):4595-9.

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