Drug Information

Drug General Information
Drug ID
D0TA0L
Former ID
DNC005388
Drug Name
FR-181157
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541163]
Formula
C30H27NO4
InChI
InChI=1S/C30H27NO4/c32-27(33)20-34-25-16-9-10-21(19-25)18-24-15-7-8-17-26(24)30-31-28(22-11-3-1-4-12-22)29(35-30)23-13-5-2-6-14-23/h1-6,9-14,16-17,19,24H,7-8,15,18,20H2,(H,32,33)
InChIKey
QVZSFHJAGXKMMQ-UHFFFAOYSA-N
PubChem Compound ID
10141039
PubChem Substance ID
39979461, 78840780, 136105813, 178102478, 233515258
Target and Pathway
Target(s) Prostaglandin E2 receptor, EP4 subtype Target Info Inhibitor [527530]
Prostaglandin E2 receptor EP3 subtype Target Info Inhibitor [527579]
Prostacyclin receptor Target Info Inhibitor [528308]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
Renin secretion
Pathways in cancerhsa04020:Calcium signaling pathway
cAMP signaling pathway
Regulation of lipolysis in adipocytes
Pathways in cancerhsa04080:Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Platelet activation
NetPath Pathway FSH Signaling Pathway
IL2 Signaling Pathway
IL4 Signaling Pathway
TGF_beta_Receptor Signaling PathwayNetPath_14:IL2 Signaling Pathway
Pathway Interaction Database Thromboxane A2 receptor signaling
PathWhiz Pathway Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin
Reactome Prostanoid ligand receptors
G alpha (s) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (i) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signalingWP98:Prostaglandin Synthesis and Regulation
Endothelin Pathways
Platelet homeostasis
GPCR downstream signaling
References
Ref 541163(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5854).
Ref 527530J Med Chem. 2005 May 5;48(9):3103-6.Discovery of diphenyloxazole and Ndelta-Z-ornithine derivatives as highly potent and selective human prostaglandin EP(4) receptor antagonists.
Ref 527579Bioorg Med Chem Lett. 2005 Jul 1;15(13):3284-7.Metabolism investigation leading to novel drug design: orally active prostacyclin mimetics. Part 4.
Ref 528308Bioorg Med Chem Lett. 2006 Sep 15;16(18):4861-4. Epub 2006 Jul 11.Replacing the cyclohexene-linker of FR181157 leading to novel IP receptor agonists: orally active prostacyclin mimetics. Part 6.

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