Drug Information

Drug General Information
Drug ID
D00HXX
Former ID
DIB020805
Drug Name
RGFP966
Synonyms
RGFP-966
Drug Type
Small molecular drug
Indication Discovery agent Investigative [532184]
Formula
C21H19FN4O
InChI
InChI=1S/C21H19FN4O/c22-18-9-10-20(19(23)13-18)25-21(27)11-8-17-14-24-26(15-17)12-4-7-16-5-2-1-3-6-16/h1-11,13-15H,12,23H2,(H,25,27)/b7-4+,11-8+
InChIKey
BLVQHYHDYFTPDV-VCABWLAWSA-N
PubChem Compound ID
56650312
PubChem Substance ID
134427692, 172823453, 187051802, 208265487, 210275002, 210280640, 226088052, 237560605, 237560607, 251910742, 252160814, 252473249
Target and Pathway
Target(s) Histone deacetylase-3 Target Info Inhibitor [532184]
KEGG Pathway Thyroid hormone signaling pathway
Alcoholism
Viral carcinogenesis
PANTHER Pathway Wnt signaling pathway
Pathway Interaction Database Signaling events mediated by HDAC Class II
Signaling events mediated by HDAC Class I
Retinoic acid receptors-mediated signaling
Validated targets of C-MYC transcriptional repression
Regulation of retinoblastoma protein
References
Ref 532184HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner. Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2647-52.
Ref 532184HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner. Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2647-52.

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