Drug Information

Drug General Information
Drug ID
D0P3FZ
Former ID
DNC012930
Drug Name
5-(piperidin-4-yl)isothiazol-3-ol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528034]
Formula
C8H12N2OS
Canonical SMILES
C1CNCCC1C2=CC(=O)NS2
InChI
1S/C8H12N2OS/c11-8-5-7(12-10-8)6-1-3-9-4-2-6/h5-6,9H,1-4H2,(H,10,11)
InChIKey
WUINUICOEAZPLK-UHFFFAOYSA-N
PubChem Compound ID
10035301
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor Target Info Inhibitor [528034]
Gamma-aminobutyric acid receptor subunit gamma-2 Target Info Inhibitor [528034]
Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Inhibitor [528034]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transportWP706:SIDS Susceptibility Pathways
Iron uptake and transport
References
Ref 528034J Med Chem. 2006 Feb 23;49(4):1388-96.Potent 4-arylalkyl-substituted 3-isothiazolol GABA(A) competitive/noncompetitive antagonists: synthesis and pharmacology.
Ref 528034J Med Chem. 2006 Feb 23;49(4):1388-96.Potent 4-arylalkyl-substituted 3-isothiazolol GABA(A) competitive/noncompetitive antagonists: synthesis and pharmacology.

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