Drug Information

Drug General Information
Drug ID
D0Y6OL
Former ID
DIB018427
Drug Name
[3H]U46619
Synonyms
[3H]U 46619
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539271]
Formula
C21H34O4
InChI
InChI=1S/C21H34O4/c1-2-3-6-9-17(22)12-13-19-18(16-14-20(19)25-15-16)10-7-4-5-8-11-21(23)24/h4,7,12-13,16-20,22H,2-3,5-6,8-11,14-15H2,1H3,(H,23,24)/b7-4-,13-12+/t16-,17+,18+,19-,20-/m1/s1
InChIKey
LQANGKSBLPMBTJ-BRSNVKEHSA-N
PubChem Compound ID
5311493
PubChem Substance ID
7980859, 11532954, 12013056, 26754819, 26754820, 47588764, 48184758, 50110789, 57359501, 75369383, 85788966, 92309950, 99300863, 99302382, 103618489, 104046445, 104133960, 124800996, 135003867, 135651212, 135651289, 179205573, 188919927, 237362080, 241375699, 252156196, 252365326, 252455674
Target and Pathway
Target(s) Thromboxane A2 receptor Target Info Agonist [525673]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Platelet activation
Reactome Prostanoid ligand receptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Thromboxane signalling through TP receptor
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Signal amplification
GPCR ligand binding
GPCR downstream signaling
References
Ref 539271(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1974).
Ref 525673The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93.

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