Drug Information

Drug General Information
Drug ID
D02OKK
Former ID
DNC001314
Drug Name
SDZ 216-525
Drug Type
Small molecular drug
Indication Discovery agent Terminated [542751], [544906]
Formula
C25H28N4O5S
InChI
InChI=1S/C25H28N4O5S/c1-34-25(31)21-17-19-20(26-21)8-6-9-22(19)28-15-13-27(14-16-28)11-4-5-12-29-24(30)18-7-2-3-10-23(18)35(29,32)33/h2-3,6-10,17,26H,4-5,11-16H2,1H3
InChIKey
LPPRLWFUMJHAKF-UHFFFAOYSA-N
PubChem Compound ID
3037456
PubChem Substance ID
10048740, 14859761, 36105338, 47880065, 48029622, 57353622, 74716829, 85213735, 111643569, 135161204, 135651033, 136350339, 227291182, 241034876
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Antagonist [538050]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 542751(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 78).
Ref 544906Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001469)
Ref 538050Influence of 5-HT1A receptor antagonism on plus-maze behaviour in mice. II. WAY 100635, SDZ 216-525 and NAN-190. Pharmacol Biochem Behav. 1997 Oct;58(2):593-603.

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