Drug Information

Drug General Information
Drug ID
D06GAI
Former ID
DNC012972
Drug Name
1-(4-chlorophenyl)-4-phenyl-1H-imidazole
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528080]
Formula
C15H11ClN2
Canonical SMILES
C1=CC=C(C=C1)C2=CN(C=N2)C3=CC=C(C=C3)Cl
InChI
1S/C15H11ClN2/c16-13-6-8-14(9-7-13)18-10-15(17-11-18)12-4-2-1-3-5-12/h1-11H
InChIKey
CPDGQKJPYYDYQG-UHFFFAOYSA-N
PubChem Compound ID
12718449
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Inhibitor [528080]
Gamma-aminobutyric acid receptor Target Info Inhibitor [528080]
Gamma-aminobutyric acid receptor subunit gamma-2 Target Info Inhibitor [528080]
Gamma-aminobutyric acid receptor subunit beta-2 Target Info Inhibitor [528080]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
Serotonergic synapse
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 528080J Med Chem. 2006 Mar 23;49(6):1855-66.Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors.
Ref 528080J Med Chem. 2006 Mar 23;49(6):1855-66.Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors.

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