Drug Information

Drug General Information
Drug ID
D09IRF
Former ID
DIB018166
Drug Name
[125I]PTA-OH
Synonyms
I-PTA-OH
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539278]
Formula
C25H36INO4
InChI
InChI=1S/C25H36INO4/c1-25(2)17-13-20(25)19(7-5-3-4-6-8-24(30)31)22(14-17)27-15-18(28)11-16-9-10-23(29)21(26)12-16/h3,5,9-10,12,17-20,22,27-29H,4,6-8,11,13-15H2,1-2H3,(H,30,31)/b5-3+/i26-2
InChIKey
RCPAWLXQBMAVGJ-WEGMHNBISA-N
PubChem Compound ID
6438322
PubChem Substance ID
43031334, 47805501, 48253908, 51567860, 114555824, 135079162, 136350484, 179293823
Target and Pathway
Target(s) Thromboxane A2 receptor Target Info Antagonist [533468]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Platelet activation
Reactome Prostanoid ligand receptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Thromboxane signalling through TP receptor
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Signal amplification
GPCR ligand binding
GPCR downstream signaling
References
Ref 539278(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1981).
Ref 533468Binding of thromboxane A2/prostaglandin H2 agonists to human platelets. Br J Pharmacol. 1987 May;91(1):223-7.

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