Drug Information

Drug General Information
Drug ID
D0E5CI
Former ID
DNC011435
Drug Name
8-Piperazin-1-yl-imidazo[1,2-a]pyrazine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526778]
Formula
C10H13N5
Canonical SMILES
C1CN(CCN1)C2=NC=CN3C2=NC=C3
InChI
1S/C10H13N5/c1-5-14(6-2-11-1)9-10-13-4-8-15(10)7-3-12-9/h3-4,7-8,11H,1-2,5-6H2
InChIKey
NSHLOJVJEGEMSF-UHFFFAOYSA-N
PubChem Compound ID
131268
Target and Pathway
Target(s) Alpha-1D adrenergic receptor Target Info Inhibitor [526778]
Alpha-1A adrenergic receptor Target Info Inhibitor [526778]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretionhsa04020:Calcium signaling pathway
AMPK signaling pathway
Salivary secretion
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
G alpha (12/13) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP58:Monoamine GPCRs
Endothelin Pathways
AMPK Signaling
References
Ref 526778J Med Chem. 1992 Oct 16;35(21):3845-57.Synthesis and hypoglycemic activity of substituted 8-(1-piperazinyl)imidazo[1,2-a]pyrazines.
Ref 526778J Med Chem. 1992 Oct 16;35(21):3845-57.Synthesis and hypoglycemic activity of substituted 8-(1-piperazinyl)imidazo[1,2-a]pyrazines.

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