Drug Information

Drug General Information
Drug ID
D03VHK
Former ID
DIB020170
Drug Name
L-748337
Synonyms
L-748,337; L 748337
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540555]
Formula
C26H31N3O5S
InChI
InChI=1S/C26H31N3O5S/c1-20(30)28-17-22-6-5-7-25(16-22)34-19-24(31)18-27-15-14-21-10-12-23(13-11-21)29-35(32,33)26-8-3-2-4-9-26/h2-13,16,24,27,29,31H,14-15,17-19H2,1H3,(H,28,30)/t24-/m0/s1
InChIKey
AWIONHVPTYTSHZ-DEOSSOPVSA-N
PubChem Compound ID
10028830
PubChem Substance ID
15010436, 22456464, 44145903, 77637444, 81065628, 135698831, 162821947, 178100761, 204370381, 229684225, 241054477, 241376114, 242677753, 249617687, 252156768
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Antagonist [525542]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 540555(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3932).
Ref 525542Potent and selective human beta(3)-adrenergic receptor antagonists. J Pharmacol Exp Ther. 1999 Aug;290(2):649-55.

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