Drug Information

Drug General Information
Drug ID
D0I4FF
Former ID
DIB018531
Drug Name
20-hydroxy-LTB4
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540345]
Formula
C20H32O5
InChI
InChI=1S/C20H32O5/c21-17-10-6-2-1-3-7-12-18(22)13-8-4-5-9-14-19(23)15-11-16-20(24)25/h3-5,7-9,13-14,18-19,21-23H,1-2,6,10-12,15-17H2,(H,24,25)/b5-4+,7-3-,13-8+,14-9-/t18-,19-/m1/s1
InChIKey
PTJFJXLGRSTECQ-PSPARDEHSA-N
PubChem Compound ID
5280745
PubChem Substance ID
7409, 801683, 4266084, 8143280, 8616382, 15002239, 24895660, 26754794, 39289786, 57357856, 77836670, 104046422, 113853910, 126524105, 135651386, 136351796, 137078321, 142970211, 179205546, 226509169, 242387352, 252371509, 252463282
Target and Pathway
Target(s) Leukotriene B4 receptor 2 Target Info Agonist [534395]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Reactome Leukotriene receptors
G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 540345(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3399).
Ref 534395A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis. Nature. 1997 Jun 5;387(6633):620-4.

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