Drug Information

Drug General Information
Drug ID
D0P3ZK
Former ID
DIB019105
Drug Name
CFTRinh-172
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467498]
Formula
C18H10F3NO3S2
InChI
InChI=1S/C18H10F3NO3S2/c19-18(20,21)12-2-1-3-13(9-12)22-15(23)14(27-17(22)26)8-10-4-6-11(7-5-10)16(24)25/h1-9H,(H,24,25)
InChIKey
JIMHYXZZCWVCMI-UHFFFAOYSA-N
PubChem Compound ID
504670
PubChem Substance ID
5973108, 11190275, 38690013, 79639269, 109725550, 125431056, 125950049, 163126282, 169565688, 178100974, 227183203, 244722640
Target and Pathway
Target(s) cystic fibrosis transmembrane conductance regulator Target Info Blocker (channel blocker) [543927]
KEGG Pathway ABC transporters
cAMP signaling pathway
AMPK signaling pathway
Gastric acid secretion
Pancreatic secretion
Bile secretion
Vibrio cholerae infection
Reactome ABC-family proteins mediated transport
WikiPathways ABC-family proteins mediated transport
References
Ref 467498(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4153).
Ref 543927(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 707).

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