Drug Information

Drug General Information
Drug ID
D01YBD
Former ID
DNC012799
Drug Name
2-(4-Methyl-piperazin-1-yl)-4-phenyl-pyrimidine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551319]
Formula
C15H18N4
Canonical SMILES
CN1CCN(CC1)C2=NC=CC(=N2)C3=CC=CC=C3
InChI
1S/C15H18N4/c1-18-9-11-19(12-10-18)15-16-8-7-14(17-15)13-5-3-2-4-6-13/h2-8H,9-12H2,1H3
InChIKey
QHOBPFOGFURKFZ-UHFFFAOYSA-N
PubChem Compound ID
10332554
Target and Pathway
Target(s) 5-hydroxytryptamine 2A receptor Target Info Inhibitor [551319]
5-hydroxytryptamine 1A receptor Target Info Inhibitor [551319]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04024:cAMP signaling pathway
PANTHER Pathway 5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP722:Serotonin HTR1 Group and FOS Pathway
References
Ref 5513194-(3-furyl)-2-(4-methylpiperazino)pyrimidines: Potent 5-HT2A receptor antagonists, Bioorg. Med. Chem. Lett. 7(13):1635-1638 (1997).
Ref 5513194-(3-furyl)-2-(4-methylpiperazino)pyrimidines: Potent 5-HT2A receptor antagonists, Bioorg. Med. Chem. Lett. 7(13):1635-1638 (1997).

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