TTD | Drug: D03GYK

Drug General Information
Drug ID	D03GYK
Former ID	DPR000067
Drug Name	Laropiprant+niacin
Synonyms	Tredaptive (TN)
Drug Type	Small molecular drug
Indication	Dyslipidaemias [ICD9: 272; ICD10:E78]		Discontinued in Phase 3	[522926]
Company	Merck
Formula	C27H24ClFN2O6S
Canonical SMILES	CS(=O)(=O)C1=C2C(=CC(=C1)F)C3=C(N2CC4=CC=C(C=C4)Cl)C(CC<br />3)CC(=O)O.C1=CC(=CN=C1)C(=O)O
InChI	1S/C21H19ClFNO4S.C6H5NO2/c1-29(27,28)18-10-15(23)9-17-16-7-4-13(8-19(25)26)20(16)24(21(17)18)11-12-2-5-14(22)6-3-12;8-6(9)5-2-1-3-7-4-5/h2-3,5-6,9-10,13H,4,7-8,11H2,1H3,(H,25,26);1-4H,(H,8,9)/t13-;/m1./s1
InChIKey	ZZRFQBQNZLFESZ-BTQNPOSSSA-N
CAS Number	CAS 571170-77-9
PubChem Compound ID	11948701
PubChem Substance ID	17384843, 35019603, 75159583, 135264384
SuperDrug ATC ID	C04AC01
SuperDrug CAS ID	cas=000059676
Target and Pathway
Target(s)	Prostaglandin D2 receptor	Target Info	Antagonist	[536740]
KEGG Pathway	Neuroactive ligand-receptor interaction
Pathway Interaction Database	Thromboxane A2 receptor signaling
PathWhiz Pathway	Intracellular Signalling Through PGD2 receptor and Prostaglandin D2
Reactome	Prostanoid ligand receptors
Reactome	G alpha (s) signalling events
WikiPathways	Prostaglandin Synthesis and Regulation
	GPCRs, Class A Rhodopsin-like
	Small Ligand GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 522926	ClinicalTrials.gov (NCT01054508) Effect of Tredaptive on Serum Lipoproteins and Inflammatory Markers. U.S. National Institutes of Health.
Ref 536740	Emerging antidyslipidemic drugs. Expert Opin Emerg Drugs. 2008 Jun;13(2):363-81.

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Drug Information