Drug Information

Drug General Information
Drug ID
D06DSF
Former ID
DNC008334
Drug Name
5-(2-oxoindolin-5-yl)-1H-pyrrole-2-carbonitrile
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529352]
Formula
C13H9N3O
Canonical SMILES
C1C2=C(C=CC(=C2)C3=CC=C(N3)C#N)NC1=O
InChI
1S/C13H9N3O/c14-7-10-2-4-11(15-10)8-1-3-12-9(5-8)6-13(17)16-12/h1-5,15H,6H2,(H,16,17)
InChIKey
TVDRXBFEEAXOTN-UHFFFAOYSA-N
PubChem Compound ID
24824217
Target and Pathway
Target(s) Progesterone receptor Target Info Inhibitor [529352]
KEGG Pathway Oocyte meiosis
Progesterone-mediated oocyte maturation
Pathway Interaction Database Cellular roles of Anthrax toxin
Reactome Nuclear signaling by ERBB4
Nuclear Receptor transcription pathway
WikiPathways Ovarian Infertility Genes
Signaling by ERBB4
Nuclear Receptors
References
Ref 529352J Med Chem. 2008 Mar 27;51(6):1861-73. Epub 2008 Mar 5.Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348).
Ref 529352J Med Chem. 2008 Mar 27;51(6):1861-73. Epub 2008 Mar 5.Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348).

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