Drug Information

Drug General Information
Drug ID
D0L5YC
Former ID
DNC011818
Drug Name
8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551246]
Formula
C11H15NO
Canonical SMILES
COC1=CC=CC2=C1CC(CC2)N
InChI
1S/C11H15NO/c1-13-11-4-2-3-8-5-6-9(12)7-10(8)11/h2-4,9H,5-7,12H2,1H3
InChIKey
RVKOHSCTEHZRRT-UHFFFAOYSA-N
PubChem Compound ID
10197933
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Inhibitor [551246]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 551246Synthesis of new derivatives of 8-OH-DPAT: Influence of substitution on the aromatic ring on the pharmacological profile, Bioorg. Med. Chem. Lett. 3(10):2035-2038 (1993).
Ref 551246Synthesis of new derivatives of 8-OH-DPAT: Influence of substitution on the aromatic ring on the pharmacological profile, Bioorg. Med. Chem. Lett. 3(10):2035-2038 (1993).

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