Drug Information

Drug General Information
Drug ID
D03MTM
Former ID
DIB020119
Drug Name
JTE-013
Synonyms
JTE 013; JTE013; pyrazolopyridine analog
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539933]
Formula
C17H19Cl2N7O
InChI
InChI=1S/C17H19Cl2N7O/c1-8(2)11-7-14(22-16-15(11)9(3)25-26(16)4)23-24-17(27)20-10-5-12(18)21-13(19)6-10/h5-8H,1-4H3,(H,22,23)(H2,20,21,24,27)
InChIKey
RNSLRQNDXRSASX-UHFFFAOYSA-N
PubChem Compound ID
10223146
PubChem Substance ID
15224120, 22611596, 26759554, 29215534, 40337634, 58816312, 76865828, 85787654, 91746509, 125335482, 135650448, 135653394, 162023393, 163124959, 163687301, 204370479, 231688965, 241375906, 242179345, 245561019, 252156475, 252160522, 252450300, 252457969, 252543499
Target and Pathway
Target(s) P2RY10 Target Info Antagonist [529462]
Sphingosine-1-phosphate receptor-2 Target Info Antagonist [526465]
KEGG Pathway Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
Pathway Interaction Database S1P3 pathway
Sphingosine 1-phosphate (S1P) pathway
S1P2 pathway
Reactome G alpha (i) signalling events
Lysosphingolipid and LPA receptors
WikiPathways Signal Transduction of S1P Receptor
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 539933(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2917).
Ref 526465Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist. Biochem Biophys Res Commun. 2002 Dec 6;299(3):483-7.
Ref 529462Identification of the orphan GPCR, P2Y(10) receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor. Biochem Biophys Res Commun. 2008 Jul 11;371(4):707-12.

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