Drug Information

Drug General Information
Drug ID
D0U1SF
Former ID
DIB018995
Drug Name
BMY 45778
Synonyms
BMY45778; BMY-45778
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539260]
Formula
C26H18N2O5
InChI
InChI=1S/C26H18N2O5/c29-21(30)15-31-20-13-7-12-19(14-20)24-23(27-16-32-24)26-28-22(17-8-3-1-4-9-17)25(33-26)18-10-5-2-6-11-18/h1-14,16H,15H2,(H,29,30)
InChIKey
DSRSEEYZGWTODH-UHFFFAOYSA-N
PubChem Compound ID
127861
PubChem Substance ID
4766310, 10241877, 11114086, 14807939, 29307043, 56464244, 57342353, 74914279, 85208976, 85788148, 103359404, 104366794, 126436241, 127781417, 135082450, 135650008, 135698258, 143190058, 143209858, 162022976, 163125727, 204378858, 226970402, 241182432, 241375433, 249617311
Target and Pathway
Target(s) Prostacyclin receptor Target Info Agonist [534390]
KEGG Pathway Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Platelet activation
Pathway Interaction Database Thromboxane A2 receptor signaling
PathWhiz Pathway Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin
Reactome Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
Endothelin Pathways
Platelet homeostasis
GPCR ligand binding
GPCR downstream signaling
References
Ref 539260(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1963).
Ref 534390Relaxant actions of nonprostanoid prostacyclin mimetics on human pulmonary artery. J Cardiovasc Pharmacol. 1997 Apr;29(4):525-35.

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