Drug Information

Drug General Information
Drug ID
D02QML
Former ID
DNC013368
Drug Name
1-(3-(2-methylquinolin-7-yl)phenyl)ethanone
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528922]
Formula
C18H15NO
Canonical SMILES
CC1=NC2=C(C=C1)C=CC(=C2)C3=CC(=CC=C3)C(=O)C
InChI
1S/C18H15NO/c1-12-6-7-14-8-9-17(11-18(14)19-12)16-5-3-4-15(10-16)13(2)20/h3-11H,1-2H3
InChIKey
RDDPBRGDKLSJLB-UHFFFAOYSA-N
PubChem Compound ID
44432663
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Inhibitor [528922]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 528922Bioorg Med Chem Lett. 2007 Aug 15;17(16):4415-8. Epub 2007 Jun 10.Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists.
Ref 528922Bioorg Med Chem Lett. 2007 Aug 15;17(16):4415-8. Epub 2007 Jun 10.Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists.

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