Drug Information

Drug General Information
Drug ID
D0R7VW
Former ID
DNC006455
Drug Name
4-(3-chlorophenylthio)-2-(pyridin-2-yl)pyrimidine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528038]
Formula
C15H10ClN3S
Canonical SMILES
C1=CC=NC(=C1)C2=NC=CC(=N2)SC3=CC(=CC=C3)Cl
InChI
1S/C15H10ClN3S/c16-11-4-3-5-12(10-11)20-14-7-9-18-15(19-14)13-6-1-2-8-17-13/h1-10H
InChIKey
UISOVRMNRPVABO-UHFFFAOYSA-N
PubChem Compound ID
11460771
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Inhibitor [528038]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 528038Bioorg Med Chem Lett. 2006 May 1;16(9):2467-9. Epub 2006 Feb 14.Structure-activity relationship of thiopyrimidines as mGluR5 antagonists.
Ref 528038Bioorg Med Chem Lett. 2006 May 1;16(9):2467-9. Epub 2006 Feb 14.Structure-activity relationship of thiopyrimidines as mGluR5 antagonists.

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