Drug Information

Drug General Information
Drug ID
D0PW7B
Former ID
DIB019737
Drug Name
DIDS
Synonyms
4,4'-diisothiocyanostilbene-2,2'-disulphonic acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467515]
Formula
C16H10N2O6S4
InChI
InChI=1S/C16H10N2O6S4/c19-27(20,21)15-7-13(17-9-25)5-3-11(15)1-2-12-4-6-14(18-10-26)8-16(12)28(22,23)24/h1-8H,(H,19,20,21)(H,22,23,24)
InChIKey
YSCNMFDFYJUPEF-UHFFFAOYSA-N
PubChem Compound ID
40600
PubChem Substance ID
5935356, 34706360, 50789072, 104334822, 125414539, 125616668, 129840108, 162402885, 162415640, 162865178, 178100996, 202824407, 206254875
Target and Pathway
Target(s) ClC-Kb Target Info Blocker (channel blocker) [543924]
ClC-7 Target Info Blocker (channel blocker) [531154]
ClC-Ka Target Info Blocker (channel blocker) [543923]
ClC-6 Target Info Blocker (channel blocker) [543926]
VRAC Target Info Blocker (channel blocker) [543931]
calcium activated channel anoctamin 1 Target Info Blocker (channel blocker) [543928]
Maxi Cl- Target Info Blocker (channel blocker) [531154]
Reactome Stimuli-sensing channels
References
Ref 467515(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4177).
Ref 531154The G215R mutation in the Cl-/H+-antiporter ClC-7 found in ADO II osteopetrosis does not abolish function but causes a severe trafficking defect. PLoS One. 2010 Sep 7;5(9):e12585.
Ref 543923(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 700).
Ref 543924(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 701).
Ref 543926(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 705).
Ref 543928(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 708).
Ref 543931(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 710).

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