Drug Information

Drug General Information
Drug ID
D02YFZ
Former ID
DNC011916
Drug Name
2-Piperazin-1-yl-benzonitrile
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533134]
Formula
C11H13N3
Canonical SMILES
C1CN(CCN1)C2=CC=CC=C2C#N
InChI
1S/C11H13N3/c12-9-10-3-1-2-4-11(10)14-7-5-13-6-8-14/h1-4,13H,5-8H2
InChIKey
FRICBZWJFIRJOB-UHFFFAOYSA-N
PubChem Compound ID
2735875
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Inhibitor [533134]
5-hydroxytryptamine 1D receptor Target Info Inhibitor [533134]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04024:cAMP signaling pathway
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
GPCR downstream signaling
References
Ref 533134J Med Chem. 1989 May;32(5):1052-6.Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy.
Ref 533134J Med Chem. 1989 May;32(5):1052-6.Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy.

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