Drug Information

Drug General Information
Drug ID
D0Z8EI
Former ID
DNC004022
Drug Name
6-Allyloxy-9H-purin-2-ylamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [525899]
Formula
C8H9N5O
Canonical SMILES
C=CCOC1=NC(=NC2=C1NC=N2)N
InChI
1S/C8H9N5O/c1-2-3-14-7-5-6(11-4-10-5)12-8(9)13-7/h2,4H,1,3H2,(H3,9,10,11,12,13)
InChIKey
HJMGFQNIHIHSCQ-UHFFFAOYSA-N
PubChem Compound ID
179571
Target and Pathway
Target(s) Methylated-DNA--protein-cysteine methyltransferase Target Info Inhibitor [525899]
WikiPathways DNA Damage Reversal
References
Ref 525899J Med Chem. 2000 Nov 2;43(22):4071-83.Resistance-modifying agents. 8. Inhibition of O(6)-alkylguanine-DNA alkyltransferase by O(6)-alkenyl-, O(6)-cycloalkenyl-, and O(6)-(2-oxoalkyl)guanines and potentiation of temozolomide cytotoxicity in vitro by O(6)-(1-cyclopentenylmethyl)guanine.
Ref 525899J Med Chem. 2000 Nov 2;43(22):4071-83.Resistance-modifying agents. 8. Inhibition of O(6)-alkylguanine-DNA alkyltransferase by O(6)-alkenyl-, O(6)-cycloalkenyl-, and O(6)-(2-oxoalkyl)guanines and potentiation of temozolomide cytotoxicity in vitro by O(6)-(1-cyclopentenylmethyl)guanine.

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