Drug Information

Drug General Information
Drug ID
D05QLT
Former ID
DIB018719
Drug Name
A438079
Synonyms
A-438079; A 438079
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467461]
Formula
C13H9Cl2N5
InChI
InChI=1S/C13H9Cl2N5/c14-11-5-1-4-10(12(11)15)13-17-18-19-20(13)8-9-3-2-6-16-7-9/h1-7H,8H2
InChIKey
MMPAULQSJLVKHP-UHFFFAOYSA-N
PubChem Compound ID
11673921
PubChem Substance ID
16777890, 23771730, 77470945, 103489724, 162064804, 163359979, 163620926, 163686247, 163874726, 174006407, 178100940, 185992935, 204403239, 223733307, 224047239, 231602277, 245269527
Target and Pathway
Target(s) P2X purinoceptor 7 Target Info Antagonist [528808]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Reactome The NLRP3 inflammasome
WikiPathways Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
References
Ref 467461(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4118).
Ref 528808Discovery of P2X7 receptor-selective antagonists offers new insights into P2X7 receptor function and indicates a role in chronic pain states. Br J Pharmacol. 2007 Jul;151(5):571-9. Epub 2007 Apr 30.

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