Drug Information

Drug General Information
Drug ID
D0W2BP
Former ID
DNC011258
Drug Name
N-benzyl-5-(4-chlorophenyl)nicotinamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531169]
Formula
C19H15ClN2O
Canonical SMILES
C1=CC=C(C=C1)CNC(=O)C2=CN=CC(=C2)C3=CC=C(C=C3)Cl
InChI
1S/C19H15ClN2O/c20-18-8-6-15(7-9-18)16-10-17(13-21-12-16)19(23)22-11-14-4-2-1-3-5-14/h1-10,12-13H,11H2,(H,22,23)
InChIKey
FWHXSLFSGPLDBM-UHFFFAOYSA-N
PubChem Compound ID
46032908
Target and Pathway
Target(s) Voltage-gated sodium channel subunit alpha Nav1.8 Target Info Inhibitor [531169]
PN3 Na+ channel Target Info Inhibitor [531169]
Reactome Interaction between L1 and Ankyrins
References
Ref 531169Bioorg Med Chem Lett. 2010 Nov 15;20(22):6812-5. Epub 2010 Sep 18.Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives.
Ref 531169Bioorg Med Chem Lett. 2010 Nov 15;20(22):6812-5. Epub 2010 Sep 18.Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives.

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